Dr. Dave Hepburn

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My Blog

OIL AND GAS BY DR. DAVID HEPBURN

The two most common delivery mechanisms for medical cannabis are oils or gas (as in vapour). Creams, wafers, sprays, tinctures and suppositories, while useful and fun, universally trail ingestion or inhalation methods.

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CANNABIS EFFECTIVE AND SAFE FOR DOGS WITH JOINT ISSUES

Objectives: The objectives of this study were to determine basic oral pharmacokinetics, and assess safety and analgesic efficacy of a cannabidiol (CBD) based oil in dogs with osteoarthritis (OA).

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LEGALIZING MEDICAL CANNABIS ACTUALLY IMPROVES WORKPLACE SAFETY

AIMS: The aim of this research was to determine the association between legalizing medical marijuana and workplace fatalities. DESIGN:Repeated cross-sectional data on workplace.

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CBD Induces Rapid and Sustained Antidepressant Like Effects

Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health.

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THC Inhibits Endometrial Cancer - Dr. David HEPBURN

Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health.

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Cannabis lozenges reduce pain efficiently - Dr. David Hepburn

Therapeutic use of cannabinoids, the main active ingredients of Cannabissativa L., is often hindered by their limited bioavailability and undesirable psychoactivity.We conducted an observational study in December 2016 and another one in February 2018 to investigate respectively.

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Tobacco smokers have reduced brain receptors for cannabis - Dr. David Hepburn

Previous studies showed reduction of brain cannabinoid CB1 receptors in adults with cannabis and alcohol use disorders. Preclinical data suggest that these receptors also contribute to nicotine reward and dependence.

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Cannabis leads to fewer bladder infections - Dr. David Hepburn

To further define the relationship between tetrahydrocannabinol (THC) and lower urinary tract symptoms (LUTS), specifically how THC use associates with the frequency of LUTS in young community-dwelling men in the United States.

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New study: Autism and Cannabis - Dr. David Hepburn

Study: The trial aims to study the effectiveness of cannabidivarin (CBDV) on irritability and repetitive behaviors in children with ASD.

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CBD to prevent schizophrenia? - Dr. David Hepburn

Schizophrenia is considered a debilitating neurodevelopmental psychiatric disorder and its pharmacotherapy remains problematic without recent major advances. The development of interventions able to prevent the emergence of schizophrenia would therefore represent an enormous progress.

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CBD could reverse brain aging - Dr. Dave Hepburn

Iron accumulation in the brain has been recognized as a common feature of both normal aging and neurodegenerative diseases. Cognitive dysfunction has been associated to iron excess in brain regions in humans.

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New Study: THC Reduces Neuropathic Pain - Dr. David Hepburn

To characterize the functional brain changes involved in δ-9-tetrahydrocannabinol (THC) modulation of chronic neuropathic pain.
Fifteen patients with chronic radicular neuropathic pain participated in a randomized, double-blind.

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CBD Shows More Potential in Treatment of Brain Tumour - Dr. David Hepburn

Glioblastoma multiforme (GBM) is the most frequent and aggressive type of brain tumor due, at least in part, to its poor response to current anticancer treatments.

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Majority of Pain Specialists Prescribe Cannabis - Dr. David Hepburn

The scientific study of the role of cannabis in pain medicine still lags far behind the growing use driven by public approval. Accumulated clinical experience is therefore an important source of knowledge. However, no study to date has targeted physicians who actually use cannabis in their daily practice.

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Cannabinoid Receptor Protects Against Hearing Loss Caused by Chemotherapy - Dr. David Hepburn

Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis.

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Schizophrenia More Likely to Lead to Cannabis Use…. Not the Reverse - Dr Dave Hepburn

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions.

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Cannabinoid Receptor (CB1) Plays Crucial Role in Alzheimers Disease - Dr. Dave Hepburn

Activating CB1 cannabinoid receptor has been demonstrated to produce certain therapeutic effects in animal models of Alzheimer's disease (AD). In this study, we evaluated the specific contribution of CB1 receptor to the progression of AD-like pathology in double transgenic APP/PS1 mice.

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US Study Shows Which Cannabis (and how) is Best for Insomnia - Dr. David Hepburn

We use a mobile software application (app) to measure for the first time, which fundamental characteristics of raw, natural medical Cannabis flower are associated with changes in perceived insomnia under naturalistic conditions.

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Cannabis Extract Inhibits Superbug MRSA - Dr. David Hepburn

This study examined the antimicrobial activity of Cannabis sativa, Thuja orientalis and Psidium guajava against methicillin-resistant Staphylococcus aureus (MRSA) and used a standardized purification protocol to determine the presence and abundance of bioactive compounds in the leaf extracts.

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New Study of Cannabinoids in Prostate Cancer - Dr. David Hepburn

Cannabinoids have demonstrated anticarcinogenic properties in a variety of malignancies, including in prostate cancer. In the present study, we explored the anti-cancer effects of the synthetic cannabinoid WIN 55,212-2 (WIN) in prostate cancer.

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Yet Another Cannabinoid Shows Remarkable Promise - Dr. David Hepburn

Cannabidiol (CBD), a non-intoxicating component of cannabis, or the psychoactive Δ9-tetrahydrocannabiol (THC), shows anti-hyperalgesia and anti-inflammatory properties.

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Impressive New Ways that CBD Works - Dr. Dave Hepburn

Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases,

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Those Using Cannabis Are Much More Successful Getting Off Opioids - Dr. David Hepburn

Cannabis use is common among people on opioid agonist treatment (OAT), causing concern for some care providers. However, there is limited and conflicting evidence on the impact of cannabis use on OAT outcomes.

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Move Over Epidiolex...Already! - Dr. Dave Hepburn

Both Tetrahydrocannabidiol (THC) and cannabidiol (CBD) components of cannabis, have been shown to have anticonvulsant effects. Cannabis oils are used to treat seizures in drug-resistant epilepsy (DRE).

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Sexually Activity in Rats Increased by Cannabinoid 1 Receptor Activation

The endocannabinoid anandamide (AEA) transforms half of the population of previously non-copulating (NC) rats into sexually active animals in a long-lasting manner. The aim of this work was to explore the nature of this transformation.

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Use of THC in Adolescence May Reduce Ability to Cope with Stress in Adulthood

Δ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid exposure in the adolescent period can also contribute to exacerbate behavioural deficits in adulthood.

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Cannabis use is associated with a greater likelihood for suicide attempts in adolescents

Evidence suggests that cannabis use may be associated with suicidality in adolescence. Nevertheless, very few studies have assessed this association in low- and middle-income countries (LMICs).

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Cannabis may be helpful in the treatment of children with autism in an open study

Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability .

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Singing or Running Elevate Endocannabinoids and Boosts Mood - Dr. David Hepburn

The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appetite, mood, memory and neuroprotection.

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Cannabis better than narcotics in treatment of back pain in Fibromyalgia - Dr. David Hepburn

Low back pain (LBP) occurs in many patients with fibromyalgia (FM). The current study aimed to assess the possible pain and function amelioration associated with medical cannabis therapy (MCT) in this setting.

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Exciting Promise of Role of CBD in Alzheimer’s Neuro-inflammation - Dr. David Hepburn

Neuroinflammation plays a vital role in Alzheimer’s disease and other neurodegenerative conditions. Microglia are the resident mononuclear immune cells of the central nervous system.

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The CB2 receptor plays a significant role in heart function in people with pulmonary hypertension.

Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia.

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New Research Indicates Benefit of Cannabis in Autism - Dr. David Hepburn

Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabi.

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New Research Indicates Benefit of Cannabis in Autism - Dr. David Hepburn

Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems.

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